Week 1 Discussion: For this Discussion, you examine a case study and explain the disease that is suggested. You examine the symptoms reported and explain the cells that are involved and potential alterations and impacts

At its core, pathology is the study of disease. Diseases occur for many reasons. But some, such as cystic fibrosis and Parkinson’s Disease, occur because of alterations that prevent cells from functioning normally.

Understanding of signals and symptoms of alterations in cellular processes is a critical step in diagnosis and treatment of many diseases. For the Advanced Practice Registered Nurse (APRN), this understanding can also help educate patients and guide them through their treatment plans.

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To prepare:

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By Day 1 of this week, you will be assigned to a specific scenario for this Discussion. Please see the “Course Announcements” section of the classroom for your assignment from your Instructor.

For this Discussion, you examine a case study and explain the disease that is suggested. You examine the symptoms reported and explain the cells that are involved and potential alterations and impacts.

Post an explanation of the disease highlighted in the scenario you were provided. Include the following in your explanation:

The role genetics plays in the disease.

Why the patient is presenting with the specific symptoms described.

The physiologic response to the stimulus presented in the scenario and why you think this response occurred.

The cells that are involved in this process.

How another characteristic (e.g., gender, genetics) would change your response.

Scenario 1: Patient is a 22-year-old male who presents to the clinic for allergy immunotherapy “allergy shots”. The patient is administered the medication the injection and waits 30 minutes to leave the center. As the patient is leaving, he begins to complain of having difficulty swallowing, nausea, and feeling weak. His vitals are 100/76, HR 120, Resp 24, O2 sat 95%. The patient is now seating in a tripod position on the table.

Review the following Video Resources and Content Pages in the Lecturio Platform by clicking button below labeled Load Week 1: Learning Resources in a new window.

Website for these videos: https://waldenu.lecturio.com/#/course/a/88725

Basic Cell Housekeeping Functions (4:24 min)

Subcellular Organization (4:57 min)

Mechanisms of Cell Injury (7:06 min)

Etiologies of Cellular Injury: Introduction (3:25 min)

Chemical Agents – Etiologies of Cellular Injury (4:13 min)

Hypoxia – Etiologies of Cellular Injury (2:25 min)

Infectious Agents – Etiologies of Cellular Injury (3:21 min)

ATP Depletion – Mechanisms of Cellular Injury (4:22)

Overview of Cellular Injury (10:27 min)

Mitochondria in Cellular Injury (1:11 min)

Frameworks of Cellular Pathology (12:54 min)

Classical Genetic Assumptions – Classic Mendelian Genetics (2:42 min)

Anaphylaxis and Food Allergy (Hypersensitivity) in Children (7:13 min)

Urticara (Hives) and Angioedema in Children (6:34 min)

Note: These readings are intended to serve as supplementary to the Lecturio content provided in this course. Please refer/review these supplementary resources should you need help in reinforcing concepts and in preparation for completing this week’s Assessments.

McCance, K. L. & Huether, S. E. (2019). Pathophysiology: The biologic basis for disease in adults and children (8th ed.). St. Louis, MO: Mosby/Elsevier.

Chapter 1: Cellular Biology; Summary ReviewChapter 2: Altered Cellular and Tissue Biology: Environmental Agents (pp. 46-61; begin again with Manifestations of Cellular Injury pp. 83-97); Summary Review

Chapter 3: The Cellular Environment: Fluids and Electrolytes, Acids, and Bases

Chapter 4: Genes and Genetic Diseases (stop at Elements of formal genetics); Summary Review

Chapter 5: Genes, Environment-Lifestyle, and Common Diseases (stop at Genetics of common diseases); Summary Review

Justiz-Vaillant, A. A., & Zito, P. M. (2019). Immediate hypersensitivity reactions Download Immediate hypersensitivity reactions. In StatPearls. Treasure Island, FL: StatPearls Publishing. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK513315/

Credit Line: Immediate Hypersensitivity Reactions – StatPearls – NCBI Bookshelf. (2019, June 18). Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK513315/. Used with permission of Stat Pearls

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Week 1 Discussion: For this Discussion, you examine a case study and explain the disease that is suggested. You examine the symptoms reported and explain the cells that are involved and potential alterations and impacts